https://en.wikipedia.org/wiki/Glucosepane

The Present State of Progress Towards Clearing Glucosepane Cross-Links, a Contributing Cause of Degenerative Aging

Wrinkled skin we can live with, but blood vessel stiffening produces hypertension, structural failure of tiny vessels in the brain, detrimental remodeling of heart and blood vessel structures, cardiovascular disease, and death. Given all of this it is nothing short of amazing that it remains a struggle to find funding to advance the development of glucosepane cross-link breaker drugs. A single effective drug candidate could largely remove this sizable contribution to the aging process.

Recent Studies of Advanced Glycation End-Products in Aging and Age-Related Disease

http://www.jbc.org/content/280/13/12310.full

arterial stiffness  mechanism

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3078647/

http://atvb.ahajournals.org/content/25/5/932.full

https://en.wikipedia.org/wiki/Alagebrium

http://www.arteriograph.hu/downloads/Ageing/Aging%20and%20Arterial%20Stiffness.pdf

http://www.bumc.bu.edu/evanscenteribr/the-arcs/the-arcs/mechanisms-and-treatment-of-arterial-stiffness/

 

 

http://biomedgerontology.oxfordjournals.org/content/65A/9/963.full

http://joe.endocrinology-journals.org/content/221/3/405.full

 

 

 

 

 

http://www.wjgnet.com/1949-8462/full/v4/i4/90.htm

http://sci.life-extension.narkive.com/FXWzozRK/elucidating-age-associated-stiffness

http://www.karger.com/Article/PDF/334668

reorganization of proteins arterial  stiffness

 

reorganization of collagen fibers arterial  stiffness

http://www.mate.tue.nl/mate/pdfs/3160.pdf

http://link.springer.com/article/10.1007/s10237-007-0078-x

http://onlinelibrary.wiley.com/doi/10.1046/j.1467-2494.1998.171747.x/abstract

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC517818/

https://eurheartj.oxfordjournals.org/content/27/21/2588

http://linkinghub.elsevier.com/retrieve/pii/S0753332205800083?via=sd

http://atvb.ahajournals.org/content/25/5/932.short

www.sciencedirect.com/science/article/pii/S0272638604015677

http://www.nature.com/jhh/journal/v22/n10/abs/jhh200836a.html

http://circ.ahajournals.org/content/105/10/1202.short

http://ajh.oxfordjournals.org/content/18/7/930.short

http://hyper.ahajournals.org/content/38/2/227.short – wtf

 

Reducing Hypertension in Old People Significantly Reduces Cardiovascular Risk

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